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Method of Producing Ginsenoside Rh1
This patented probiotic-enzymatic biotransformation technology describes a scientific method to produce active ginsenoside Rh1 (metabolized ginsenoside) from ginseng root extracts using Bifidobacteriam sp.

Pharmacological effects of Ginsenoside Rh1

  1. Anti-allergy effect
  2. Anti-inflammation effect
  3. Cytotoxic effects on various cancer cell lines
  4. Prevention of tumor cell proliferation and differentiation
  5. Inhibition of liver disease promotion
  6. Prevention of blood platelet coagulation

Clinical papers on Ginsenoside Rh1 (www.pubmed.com – U.S. National Library of Medicine, National Institute of Health

  1. Control of phenotypic expression of cultured B16 melanoma cells by plant glycosides. Cancer Res. 45: 2781-2784 (1985)
  2. Plant-glycoside modulation of cell surface related to control of differentiation in cultured B16 melanoma cells. Cancer Res. 47: 3863-3867 (1987)
  3. Immunocytochemical localization of rH1 sodium channel in adult rat heart atria and ventricle. Presence in terminal intercalated disks. Circulation. 1996 Dec 15; 94(12):3083-6.
  4. Anti-invasive activity of ginsenoside Rh1 and Rh2 in the HT1080 cells. J. Ginseng Res. 22: 216-221 (1998)
  5. Pharmacological properties of a new aziridinylbenzoquinone, RH1 (2,5-diaziridinyl-3-(hydroxymethyl)-6-methyl-1,4-benzoquinone), in mice – cytochrome b5 reductase in human tumour cells. Biochemical Pharmacology, Volume 59,Number 7, 1 April 2000, pp. 831-837(7)
  6. A ginsenoside-Rh1, a component of ginseng saponin, activates estrogen receptor in human breast carcinoma MCF-7 cells. J. Steroid Biochem Mol Biol. 2003 Mar; 84(4):463-8.
  7. Ginsenoside Rh1 possesses antiallergic and anti-inflammatory activities. Int. Arch. Allergy Immunol. 133: 113-120 (2004)
  8. RH1 Induces Cellular Damage in an NAD(P)H:Quinone. Oxidoreductase 1-Dependent Manner: Relationship between DNA Cross-linking, Cell Cycle Perturbations, and Apoptosis THE JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, Vol. 313, No. 2
  9. Isolation of Ginsenoside Rh1 and Compound K from Fermented Ginseng and Efficacy Assessment on Systemic Anaphylactic Shock. Food Sci.Biotechnol.Vol.17,No.4,pp.000~000(2008)